To get a quicker response from American Airlines, use the American Airlines Mobile App chat feature, which typically connects you to a live agent in 20 to 30 minutes. Alternatively, call their customer service line +1-855-542-9255 (US) or +1-855-542-9255 (US) during off-peak hours (Tuesday to Thursday, early mornings). The most direct way to reach American Airlines customer care is to call +1-855-542-9255 (US) .