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The Quantu Project aims to identify ways to slow cognitive decline and improve brain health. We study daily behavior as well as cellular and molecular factors than can influence brain health across a lifespan. 

Quantu Project volunteers wear fitness devices, take cognitive assessments and/or provide biological samples allowing researchers access to exercise, sleep and other biological measurements that can be correlated to how their brain cells are functioning and to cognitive performance. As data is collected, patterns in behavior/neural activity can be isolated and studied further with the goal of discovering mechanisms that (1) cause neurodegeneration, (2) stimulate repair and regeneration of brain tissue, and/or (2) promote healthy brain function. 

 

Purpose of the Study and Reason for Your Involvement

If you are providing consent for someone else (e.g., your child, a next-of-kin, or someone for whom you are the legal guardian or are designated as a surrogate decision maker on a medical power of attorney), please note that in the sections that follow the word “you” refers to the person for whom you are providing consent.  

The purpose of this study is to record daily human activities and to develop predictive models of physical activity. We hope this study will enable researchers to test and validate new technologies that may subsequently be used to study and inform researchers and potentially caregivers regarding Alzheimer's Disease and other forms of neurological disorders, neurodevelopmental disorders, and diseases that may cause neurological changes (i.e. COVID-19). 

To achieve this overall goal, we will collect the following: 

(1) Wearable device data by recording daily human activities (sleep, heartrate, oxygen levels and steps walked). Fitbit is the wearable fitness device we are currently using for this study, and henceforth it will be called “the device” or “activity tracker.”  This will also involve downloading the Fitbit app to your smart cell phone. 

a. Research personnel will provide the device to you. 
b. Data from the device will be downloaded to UTSA research files and kept secure. 
c. You will need to notify the research team via phone or email if the activity tracker malfunctions or is lost. Another wearable device will be provided if you are consistently compliant with wearing the activity tracker (>75% of time since the device was activated). 

(2) Stem cell, proteomic, epigentic and genetic data from blood samples. DNA testing will be used to determine if you carry known genes that increase the risk of developing Alzheimer’s Disease and other neurological disorders.  

a. Researchers from this protocol will identify, recruit, and consent you for this study. You will have your biospecimens collected at your clinic. The biospecimens will then be sent to UTSA and collaborating facilities for processing, storage, and research. 
b. Identifying information about your health will be stored at UTSA, including name, gender, diagnosis, past medical history, and disease-relevant history. All identifying information will be kept secure at UTSA on UTSA servers. Samples and data will be de-identified before sharing with collaborators. 
c. When a commercial DNA testing company is used for DNA testing (i.e. 23andMe), you will be given access to the data/app as provided by the company.

(3) Recorded PET/fMRI, PSG, and OCT retinal image data from a subset of the study volunteers. 

a. This data will be transferred from health science centers or collaborating hospitals and clinics over secure internet. All scans will be for research purposes only. 
b. PET scans will be used to measure blood flow, oxygen use, and will be conducted as an outpatient procedure. 
c. MRI imaging will be used to measure brain activity (note, this does not use radiation). This will be used to detect changes in blood oxygenation. 
d. PSG will be used to monitor EEG, EMG, EOG, EKG, and respiratory effort and flow during sleep. 
e. OCT imaging will be used to look at the health of your optic nerve. 

(4) Survey data using basic health and social questionnaires. 

(5) Medical records from collaborating clinicians. 

a. Clinicians will use their own discretion in deciding which medical records are relevant to the study (i.e., cognitive test results, apnea/hypopnea index, etc).  
b. As data is collected and analyzed by the research team, specific medical records may be requested by the research staff from the clinician. 

(6) Cognitive tests. 

(7) Olfactory tests. These self-administered tests are used to measure olfactory dysfunction (lack or decrease of sense of smell). Results will be used for research purposes only. 

(8) Results of infectious disease tests. (e.g., SARS-CoV-2, HIV, HPV, TB, EEV, Zika). Results will be used for research purposes and will not be used for clinical diagnosis or treatment.

You are being asked to participate in this research repository. A research repository is a special type of research also known as a tissue bank or data registry. A repository provides a way for researchers to store samples of tissues (for example, blood, tissue specimens obtained from biopsies, and tissues or organs removed during surgery) and medical information (for example, information from your medical record about your condition) about a person for future use in research studies. In this consent form, tissues of all types will be referred to as "tissue" and private medical information will be referred to as "data". Together, tissues and data stored in a repository are referred to as "materials".

Materials from a repository can be used in research to help find out more about the causes of disease, how to prevent it, and how to treat it. Storing tissue and information about the person who provided the tissue in a repository is one way that researchers plan for new research.

This research respository was designed because we want to learn about ways daily activity can improve cognitive behavior, and whether or how these behaviors change cellular and molecular functions in humans.

You may be placed into one of three groups to explore the connections between behavior patterns and the cellular and molecular changes in the body: 

1) One group will be asked to complete cognitive or academic training (via app, or guided, remote instruction) over a 6 week – 6-month period. Types of training may include focus and concentration exercises, language classes (including learning French, Spanish or a programming language such as Python or Java), or music lessons.  

2) One group will be asked to increase physical activity by up to 30% for 6 weeks – 6 months. Subjects will be asked to increase activity by a certain % (ex. steps walked per week) or be asked to take part in an online exercise class provided by the Quantu project.

3) One group will be asked to use artificial UV light exposure for 30 minutes per day over a 6 week – 6-month period. 

Blood draws will be collected pre-, mid- and post- intervention, from which proteomic data and neural network characterizations will be collected. 20 subjects of each cohort will be healthy controls, 20 subjects will have a 1st/2nd degree family member with Alzheimer’s Disease or a sleep disorder, and 20 subjects will have a diagnosis of AD. This study will enable researchers to test and validate new technologies that we hope will subsequently be applied to study and inform treatment of neurological diseases that contribute to cognitive decline. 

Your materials may be helpful for research whether or not you have the disease or condition that is the focus of this repository. 

Future research studies using materials from this repository may include genetic and proteomic testing.  In some cases, genetic testing of tissues can be used to indicate a risk for the development of certain diseases or to discover possible changes in a person’s future health status or life expectancy, or that of his/her children and family members.  If you provide us with your primary care physician’s name and phone number, we will provide them with a report on our findings and any subsequent imaging, test results, etc. We cannot provide this to you directly. 

There may be potential commercial benefits from the repository’s use of your materials. There are no plans to provide you with money or other compensation. 

The repository is maintained at the University of Texas San Antonio. The Principal Investigator is responsible for the repository.   

Amina Ann Qutub, Ph.D.
One UTSA Circle
SEB Suite 4.106
San Antonio, TX 78249 

You may discontinue all further participation in this research repository at any time and request that your currently stored materials no longer be used.  Contact the repository at the address provided above to notify them of your decision.  After you discontinue participation, the repository will not collect any new materials from you and will not use your banked specimens or identifiable information for any research purposes. 

Before any other processing, all data will be anonymized and stored on a secure server to prevent any unauthorized parties from gaining access to or using the data to identify you.

You may opt out of any portion of the study at any time; however, non-compliance with activity tracking may disqualify you from the study.

Finally, existing and proprietary algorithms developed over the course of the project will process the de-identified data in an effort to predict behavioral changes from current and past data.

Participant Requirements 

This study requires that you be an adult volunteering yourself or an adult with medical power-of-attorney volunteering on behalf of your charge, and you (or your charge) have the capacity to: a) give consent to participate in this study and b) wear a Fitbit tracker continuously for at least 6 months, or a child (age< 18 years) with parent or guardian’s permission. For those volunteering for the bioassays, this also requires you are willing to provide blood samples and permission to access your retinal scan, MRI and polysomnography data (where relevant). 

In order to participate in this study, you must wear the offered fitness device every day and night, including while asleep, and allow your de-identified activity data to be part of the study. You must commit to at least 6 months of activity tracking.

It is possible that this study will identify information about you that was previously unknown, such as disease status or risk. If you provide us with your primary care physician's name and phone number, we will provide them with a report on our findings and any subsequent imaging, test results, etc. We can not provide this to you directly.

Participation in the Study:

  • Whether or not you take part is up to you.
  • Participation is totally voluntary.
  • You can agree to take part in the study and later change your mind.
  • Your decision not to participate will not be held against you.
  • You may ask all the questions you want about the study before you decide.
  • Subjects who have diminished capacity and a medical power of attorney in place may participate in the study with the consent of their agent. That agent would sign the consents and contact the Principal Investigator if they wish the subject to discontinue the participation in the study. 

Contact Information:

If you have questions, concerns, complaints, or think the research has harmed you, you may talk to the research team at Phone: (210)458-7092/Email: amina.qutub@utsa.edu

This research is being overseen by an Institutional Review Board ("IRB"). You may also talk to them at (210)458-6473 or IRB@utsa.edu if you have questions regarding your rights as a research participant or other questions, concerns, or complaints.

Future Use of Your Information or Biospecimens Collected as Part of Your Participation

All of your data and specimens will be held at UTSA indefinitely or at the discretion of the research team unless you contact the research team and request otherwise.

Risks and Discomforts

The risks and discomfort associated with participation in this study are no greater than those ordinarily encountered in daily life. 

RISK: Bruising, soreness at blood draw site | LIKELIHOOD of occurrence (probability): Common | SERIOUSNESS (Magnitude): Not serious – same risk as normal doctor appointment blood draw | DURATION: Brief

RISK: fMRI – feeling claustrophobic | LIKELIHOOD of occurrence (probability):  Infrequent | SERIOUSNESS (Magnitude): Not serious – subject may withdraw | DURATION: Brief

RISK: PET scan – exposure to radiation | LIKELIHOOD of occurrence (probability):  Likely | SERIOUSNESS (Magnitude): Not serious- radiation levels will be within normal standard-of-care levels | DURATION: Brief

RISK: PSG – allergic reaction of adhesives | LIKELIHOOD of occurrence (probability):  Infrequent | SERIOUSNESS (Magnitude): Not serious – alternatives can be used  | DURATION: Brief

RISK: FitBit tracking – exposure to EM radiation/heavy metals | LIKELIHOOD of occurrence (probability):  Infrequent | SERIOUSNESS (Magnitude): Not serious- subject may withdraw | DURATION: Brief

Participant Privacy and Research Record Confidentiality

By participating in the study, you understand and agree that The University of Texas at San Antonio (UTSA) may be required to disclose your consent form, data and other personally identifiable information as required by law, regulation, subpoena or court order. Your activity data will also be collected by FitBit. Otherwise, your confidentiality will be maintained in the following manner:

Your data and consent form will be kept separate. Your consent form will be stored in a locked location on UTSA property and will not be disclosed to third parties. By participating, you understand and agree that the data and information gathered during this study may be used and published and/or disclosed by UTSA to others outside UTSA. However, your name, address, contact information and other direct personal identifiers will not be disclosed by UTSA in any such publication or dissemination of the research data and/or results.

The researchers will take the following steps to protect your identity during this study:

1. You will be assigned a number and all identifying information in the database will be stripped out.
2. Any original recordings or data files will be stored in a secured location accessible only to authorized researchers.

Your research records will not be released without your consent unless required by law or a court order. Your records may be viewed by the Institutional Review Board, but the confidentiality of your records will be protected to the extent permitted by law. The data resulting from your participation may be used in publications and/or presentations, but your identity will not be disclosed.

Your signature documents your permission for the named participant to take part in this research.

My signature below documents that the information in the consent document and any other written information was accurately explained to, and apparently understood by, the participant, and that consent was freely given by the participant.

First Participant's Name

First Name*

Last Name*

Phone*
First Participant's Date of Birth*
First Participant's Role in the Research Study

Research Procedures in the Research Study:

You will be provided a fitness tracking device (e.g. "Fitbit") if you do not currectly have a model that is compatible with the study. You will be responsible for wearing the tracker every day and keeping it charged. We ask that you charge the Fitbit during the day (not overnight). The Fitbit we provide is waterproof and may be worn in the shower, bath, or pool, but this is not necessary for the purposes of the study. On a regular basis, data will be downloaded from your device over the "web" so you must have access to a bluetooth enabled device (i.e. phone or computer) and download the Fitbit app onto that device. We will walk you through this procedure. The data will be collected on Fitbit's servers and accessed by the UTSA research team. The data will consist of activity measures such as steps walked, blood pressure, heartrate, blood oxygen level, and sleep. After being received from Fitbit, all fitness tracking data is automatically anonymized and stored on a secure server at UTSA to prevent any unauthorized parties from gaining access to or using the data to identify you. Likewise, data collected from you by other means will also be anonymized and securely stored.

For volunteers recruited through our clinical collaborations, we may request access to your medical records from our clinical partners (such as cognitive test results, apnea/hypopnea index, etc.)

1) Activity tracking: After signing a waiver to give researchers access to activity data, you may be provided with a fitness tracking device (e.g. "Fitbit") which you agree to continuously wear and keep charged. You agree not to sell, give away or otherwise transfer this device. We ask that you charge the Fitbit during the day and wear the Fitbit anytime it is not charging. On a regular basis, data will be downloaded from your device over the web. This information will consist of behavioral measures such as steps walked, blood pressure, heartrate, blood oxygen level, and sleep. The data will be collected from FitBit's servers and accessed by the UTSA research team. After being received from FitBit, all fitness tracking data is automatically anonymized and stored on a secure server to prevent any unauthorized parties from gaining access to or using the data to identify you. If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted. A Fitbit tracker will be provided to be used over the course of the study, and if you agree to allow us long-term monitoring of your physical activity, you may keep it after the completion of the study.
1) Activity tracking
2) Blood sample: This study will generally involve one visit every 6 months in which 1-3 tubes of blood will be obtained for research purposes. Subjects included in an intervention will be required to give blood before, during, and after the intervention is complete. Blood sample for adults weighing 110lbs will not exceed 550mL in an 8 week period and blood draw will not occur more frequently than 2 times per week. For adult subjects less than 110lbs, the amount drawn will not exceed the lesser of 50mL or 3mL/kg in an 8 week period and blood draw will not occur more frequently than 2 times per week. Blood will be collected from a participating lab. Participants will be assigned a numbered identifier, and all blood samples will be marked with that number only. Blood samples will be stored at UTSA, or with a collaborator pending testing. All unused blood will be stored at UTSA indefinitely or disposed of. If a participant wishes to withdraw from the study, we may request to keep specimens collected up until the point participant withdrew. The participant may elect to allow us to keep the specimen and use it for research purposes, or they may ask for it to be disposed of.
2) Blood sample
3) Non-invasive imaging: This study will use fMRI, PET and OCT scans. This data is important to chart how the biology of the brain is changing over time. All scans will be done at collaborating research sites for research purposes only. Images and scans will be marked with the participant's numbered identifier only. Digital images will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep images collected up until the point participant withdrew. The participant may elect to allow us to keep the images and use it for research purposes, or they may ask for it to be disposed of.
3) Non-invasive imaging
4) Polysomnography(PSG): This study will use PSG (sleep study) to detect sleep stages and other characteristics of sleep. This data will be used to detect EEG and sleep architecture. PSG will be performed at collaborating research sites for research purposes only. Subjects who agree to wear a tracking device during a polysomnograph will release all sleep study data to the Quantu research team. PSG will be marked with the participants numbered identifier only. PSG data will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep PSG data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be disposed of.
4) Polysomnography(PSG)
5) Cognitive Testing: This study will use cognitive testing via website/app to establish baseline cognitive function and monitor changes in cognitive ability over the course of the study.
5) Cognitive Testing
6) One night PSG + Fitbit: Subjects who are already having a PSG procedure can opt to wear a Fitbit during the night of the procedure for comparison studies. The Fitbit will be returned to sleep lab personnel after the completion of the sleep study. Subjects are welcome to join the long term study if they choose. Subjects who agree to wear a tracking device during a polysomnograph will release all sleep study data to the Quantu research team. PSG will be marked with the participants numbered identifier only. PSG data will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep PSG data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be disposed of.
6) One night PSG + Fitbit
7) Cognitive Training Intervention: You will be asked to do a series of cognitive training exercises via app or remote learning for 6 weeks - 6 months. You will be asked to give blood prior to the start of the intervention, during the intervention, and after the intervention. After the intervention is completed, you will continue to be racked via Fitbit tracker and 6 month blood draws (from the data of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes. or they may ask for it to be deleted.
7) Cognitive Training Intervention
8) Exercise Intervention: You will be asked to increase your activity levels for 6 weeks - 6 months. You will either be provided with a goal (i.e. take 10,000 steps per day) that will increase your activity level by 5-30% or be required to take an online fitness class provided by the Quantu project. You will be asked to give blood prior to the start of the intervention and after the completion of the intervention. After the intervention is completed, you will continue to be tracked vid Fitbit tracker and 6 month blood draws (from the data of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted.
8) Exercise Intervention
9) UV Light Exposure Intervention: You will be given Luminette UV light therapy glasses which they will use in the morning for 30 minutes each day for 6 weeks - 6 months. You will give blood prior to the start of the intervention and after the completion of the intervention. After the intervention is completed, You will continue to be tracked via FitBit tracker and 6 month blood draws (from the date of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted.
9) UV Light Exposure Intervention
10) DNA Testing:
10) DNA Testing
You will be asked to perform several tests of olfaction (your capacity to distinguish odors). These noninvasive tests may be self-administered and involve distinguishing between different odors included in a disposable kit. You may be asked to self-score these tests and report your scores to the Quantu research team or you may be asked to submit your responses directly via an online form or application. All test scores are anonymized for reporting, and you may not receive your test scores.
Olfactory Testing
Due to the role viruses and bacteria may play in long-term neurovasculature, cardiac and cognitive health, you may be asked about the results of related tests (i.e. SARS-CoV-2 (COVID-19)). Additionally, you may opt to have a viral or antibody test performed by a clinical facility, in which case the results of this test may be reported to the Quantu research team. All test results are anonymized for reporting and are not used for clinical diagnosis or treatment.
Results of infectious disease testing
This will allow us to access activity data prior to you being enrolled in the study. (optional)
Prior activity tracker data
First Participant's Signature*
Second Participant's Name

First Name*

Last Name*

Phone*
Second Participant's Date of Birth*
Second Participant's Role in the Research Study

Research Procedures in the Research Study:

You will be provided a fitness tracking device (e.g. "Fitbit") if you do not currectly have a model that is compatible with the study. You will be responsible for wearing the tracker every day and keeping it charged. We ask that you charge the Fitbit during the day (not overnight). The Fitbit we provide is waterproof and may be worn in the shower, bath, or pool, but this is not necessary for the purposes of the study. On a regular basis, data will be downloaded from your device over the "web" so you must have access to a bluetooth enabled device (i.e. phone or computer) and download the Fitbit app onto that device. We will walk you through this procedure. The data will be collected on Fitbit's servers and accessed by the UTSA research team. The data will consist of activity measures such as steps walked, blood pressure, heartrate, blood oxygen level, and sleep. After being received from Fitbit, all fitness tracking data is automatically anonymized and stored on a secure server at UTSA to prevent any unauthorized parties from gaining access to or using the data to identify you. Likewise, data collected from you by other means will also be anonymized and securely stored.

For volunteers recruited through our clinical collaborations, we may request access to your medical records from our clinical partners (such as cognitive test results, apnea/hypopnea index, etc.)

1) Activity tracking: After signing a waiver to give researchers access to activity data, you may be provided with a fitness tracking device (e.g. "Fitbit") which you agree to continuously wear and keep charged. You agree not to sell, give away or otherwise transfer this device. We ask that you charge the Fitbit during the day and wear the Fitbit anytime it is not charging. On a regular basis, data will be downloaded from your device over the web. This information will consist of behavioral measures such as steps walked, blood pressure, heartrate, blood oxygen level, and sleep. The data will be collected from FitBit's servers and accessed by the UTSA research team. After being received from FitBit, all fitness tracking data is automatically anonymized and stored on a secure server to prevent any unauthorized parties from gaining access to or using the data to identify you. If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted. A Fitbit tracker will be provided to be used over the course of the study, and if you agree to allow us long-term monitoring of your physical activity, you may keep it after the completion of the study.
1) Activity tracking
2) Blood sample: This study will generally involve one visit every 6 months in which 1-3 tubes of blood will be obtained for research purposes. Subjects included in an intervention will be required to give blood before, during, and after the intervention is complete. Blood sample for adults weighing 110lbs will not exceed 550mL in an 8 week period and blood draw will not occur more frequently than 2 times per week. For adult subjects less than 110lbs, the amount drawn will not exceed the lesser of 50mL or 3mL/kg in an 8 week period and blood draw will not occur more frequently than 2 times per week. Blood will be collected from a participating lab. Participants will be assigned a numbered identifier, and all blood samples will be marked with that number only. Blood samples will be stored at UTSA, or with a collaborator pending testing. All unused blood will be stored at UTSA indefinitely or disposed of. If a participant wishes to withdraw from the study, we may request to keep specimens collected up until the point participant withdrew. The participant may elect to allow us to keep the specimen and use it for research purposes, or they may ask for it to be disposed of.
2) Blood sample
3) Non-invasive imaging: This study will use fMRI, PET and OCT scans. This data is important to chart how the biology of the brain is changing over time. All scans will be done at collaborating research sites for research purposes only. Images and scans will be marked with the participant's numbered identifier only. Digital images will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep images collected up until the point participant withdrew. The participant may elect to allow us to keep the images and use it for research purposes, or they may ask for it to be disposed of.
3) Non-invasive imaging
4) Polysomnography(PSG): This study will use PSG (sleep study) to detect sleep stages and other characteristics of sleep. This data will be used to detect EEG and sleep architecture. PSG will be performed at collaborating research sites for research purposes only. Subjects who agree to wear a tracking device during a polysomnograph will release all sleep study data to the Quantu research team. PSG will be marked with the participants numbered identifier only. PSG data will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep PSG data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be disposed of.
4) Polysomnography(PSG)
5) Cognitive Testing: This study will use cognitive testing via website/app to establish baseline cognitive function and monitor changes in cognitive ability over the course of the study.
5) Cognitive Testing
6) One night PSG + Fitbit: Subjects who are already having a PSG procedure can opt to wear a Fitbit during the night of the procedure for comparison studies. The Fitbit will be returned to sleep lab personnel after the completion of the sleep study. Subjects are welcome to join the long term study if they choose. Subjects who agree to wear a tracking device during a polysomnograph will release all sleep study data to the Quantu research team. PSG will be marked with the participants numbered identifier only. PSG data will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep PSG data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be disposed of.
6) One night PSG + Fitbit
7) Cognitive Training Intervention: You will be asked to do a series of cognitive training exercises via app or remote learning for 6 weeks - 6 months. You will be asked to give blood prior to the start of the intervention, during the intervention, and after the intervention. After the intervention is completed, you will continue to be racked via Fitbit tracker and 6 month blood draws (from the data of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes. or they may ask for it to be deleted.
7) Cognitive Training Intervention
8) Exercise Intervention: You will be asked to increase your activity levels for 6 weeks - 6 months. You will either be provided with a goal (i.e. take 10,000 steps per day) that will increase your activity level by 5-30% or be required to take an online fitness class provided by the Quantu project. You will be asked to give blood prior to the start of the intervention and after the completion of the intervention. After the intervention is completed, you will continue to be tracked vid Fitbit tracker and 6 month blood draws (from the data of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted.
8) Exercise Intervention
9) UV Light Exposure Intervention: You will be given Luminette UV light therapy glasses which they will use in the morning for 30 minutes each day for 6 weeks - 6 months. You will give blood prior to the start of the intervention and after the completion of the intervention. After the intervention is completed, You will continue to be tracked via FitBit tracker and 6 month blood draws (from the date of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted.
9) UV Light Exposure Intervention
10) DNA Testing:
10) DNA Testing
You will be asked to perform several tests of olfaction (your capacity to distinguish odors). These noninvasive tests may be self-administered and involve distinguishing between different odors included in a disposable kit. You may be asked to self-score these tests and report your scores to the Quantu research team or you may be asked to submit your responses directly via an online form or application. All test scores are anonymized for reporting, and you may not receive your test scores.
Olfactory Testing
Due to the role viruses and bacteria may play in long-term neurovasculature, cardiac and cognitive health, you may be asked about the results of related tests (i.e. SARS-CoV-2 (COVID-19)). Additionally, you may opt to have a viral or antibody test performed by a clinical facility, in which case the results of this test may be reported to the Quantu research team. All test results are anonymized for reporting and are not used for clinical diagnosis or treatment.
Results of infectious disease testing
This will allow us to access activity data prior to you being enrolled in the study. (optional)
Prior activity tracker data
Third Participant's Name

First Name*

Last Name*

Phone*
Third Participant's Date of Birth*
Third Participant's Role in the Research Study

Research Procedures in the Research Study:

You will be provided a fitness tracking device (e.g. "Fitbit") if you do not currectly have a model that is compatible with the study. You will be responsible for wearing the tracker every day and keeping it charged. We ask that you charge the Fitbit during the day (not overnight). The Fitbit we provide is waterproof and may be worn in the shower, bath, or pool, but this is not necessary for the purposes of the study. On a regular basis, data will be downloaded from your device over the "web" so you must have access to a bluetooth enabled device (i.e. phone or computer) and download the Fitbit app onto that device. We will walk you through this procedure. The data will be collected on Fitbit's servers and accessed by the UTSA research team. The data will consist of activity measures such as steps walked, blood pressure, heartrate, blood oxygen level, and sleep. After being received from Fitbit, all fitness tracking data is automatically anonymized and stored on a secure server at UTSA to prevent any unauthorized parties from gaining access to or using the data to identify you. Likewise, data collected from you by other means will also be anonymized and securely stored.

For volunteers recruited through our clinical collaborations, we may request access to your medical records from our clinical partners (such as cognitive test results, apnea/hypopnea index, etc.)

1) Activity tracking: After signing a waiver to give researchers access to activity data, you may be provided with a fitness tracking device (e.g. "Fitbit") which you agree to continuously wear and keep charged. You agree not to sell, give away or otherwise transfer this device. We ask that you charge the Fitbit during the day and wear the Fitbit anytime it is not charging. On a regular basis, data will be downloaded from your device over the web. This information will consist of behavioral measures such as steps walked, blood pressure, heartrate, blood oxygen level, and sleep. The data will be collected from FitBit's servers and accessed by the UTSA research team. After being received from FitBit, all fitness tracking data is automatically anonymized and stored on a secure server to prevent any unauthorized parties from gaining access to or using the data to identify you. If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted. A Fitbit tracker will be provided to be used over the course of the study, and if you agree to allow us long-term monitoring of your physical activity, you may keep it after the completion of the study.
1) Activity tracking
2) Blood sample: This study will generally involve one visit every 6 months in which 1-3 tubes of blood will be obtained for research purposes. Subjects included in an intervention will be required to give blood before, during, and after the intervention is complete. Blood sample for adults weighing 110lbs will not exceed 550mL in an 8 week period and blood draw will not occur more frequently than 2 times per week. For adult subjects less than 110lbs, the amount drawn will not exceed the lesser of 50mL or 3mL/kg in an 8 week period and blood draw will not occur more frequently than 2 times per week. Blood will be collected from a participating lab. Participants will be assigned a numbered identifier, and all blood samples will be marked with that number only. Blood samples will be stored at UTSA, or with a collaborator pending testing. All unused blood will be stored at UTSA indefinitely or disposed of. If a participant wishes to withdraw from the study, we may request to keep specimens collected up until the point participant withdrew. The participant may elect to allow us to keep the specimen and use it for research purposes, or they may ask for it to be disposed of.
2) Blood sample
3) Non-invasive imaging: This study will use fMRI, PET and OCT scans. This data is important to chart how the biology of the brain is changing over time. All scans will be done at collaborating research sites for research purposes only. Images and scans will be marked with the participant's numbered identifier only. Digital images will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep images collected up until the point participant withdrew. The participant may elect to allow us to keep the images and use it for research purposes, or they may ask for it to be disposed of.
3) Non-invasive imaging
4) Polysomnography(PSG): This study will use PSG (sleep study) to detect sleep stages and other characteristics of sleep. This data will be used to detect EEG and sleep architecture. PSG will be performed at collaborating research sites for research purposes only. Subjects who agree to wear a tracking device during a polysomnograph will release all sleep study data to the Quantu research team. PSG will be marked with the participants numbered identifier only. PSG data will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep PSG data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be disposed of.
4) Polysomnography(PSG)
5) Cognitive Testing: This study will use cognitive testing via website/app to establish baseline cognitive function and monitor changes in cognitive ability over the course of the study.
5) Cognitive Testing
6) One night PSG + Fitbit: Subjects who are already having a PSG procedure can opt to wear a Fitbit during the night of the procedure for comparison studies. The Fitbit will be returned to sleep lab personnel after the completion of the sleep study. Subjects are welcome to join the long term study if they choose. Subjects who agree to wear a tracking device during a polysomnograph will release all sleep study data to the Quantu research team. PSG will be marked with the participants numbered identifier only. PSG data will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep PSG data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be disposed of.
6) One night PSG + Fitbit
7) Cognitive Training Intervention: You will be asked to do a series of cognitive training exercises via app or remote learning for 6 weeks - 6 months. You will be asked to give blood prior to the start of the intervention, during the intervention, and after the intervention. After the intervention is completed, you will continue to be racked via Fitbit tracker and 6 month blood draws (from the data of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes. or they may ask for it to be deleted.
7) Cognitive Training Intervention
8) Exercise Intervention: You will be asked to increase your activity levels for 6 weeks - 6 months. You will either be provided with a goal (i.e. take 10,000 steps per day) that will increase your activity level by 5-30% or be required to take an online fitness class provided by the Quantu project. You will be asked to give blood prior to the start of the intervention and after the completion of the intervention. After the intervention is completed, you will continue to be tracked vid Fitbit tracker and 6 month blood draws (from the data of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted.
8) Exercise Intervention
9) UV Light Exposure Intervention: You will be given Luminette UV light therapy glasses which they will use in the morning for 30 minutes each day for 6 weeks - 6 months. You will give blood prior to the start of the intervention and after the completion of the intervention. After the intervention is completed, You will continue to be tracked via FitBit tracker and 6 month blood draws (from the date of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted.
9) UV Light Exposure Intervention
10) DNA Testing:
10) DNA Testing
You will be asked to perform several tests of olfaction (your capacity to distinguish odors). These noninvasive tests may be self-administered and involve distinguishing between different odors included in a disposable kit. You may be asked to self-score these tests and report your scores to the Quantu research team or you may be asked to submit your responses directly via an online form or application. All test scores are anonymized for reporting, and you may not receive your test scores.
Olfactory Testing
Due to the role viruses and bacteria may play in long-term neurovasculature, cardiac and cognitive health, you may be asked about the results of related tests (i.e. SARS-CoV-2 (COVID-19)). Additionally, you may opt to have a viral or antibody test performed by a clinical facility, in which case the results of this test may be reported to the Quantu research team. All test results are anonymized for reporting and are not used for clinical diagnosis or treatment.
Results of infectious disease testing
This will allow us to access activity data prior to you being enrolled in the study. (optional)
Prior activity tracker data
Fourth Participant's Name

First Name*

Last Name*

Phone*
Fourth Participant's Date of Birth*
Fourth Participant's Role in the Research Study

Research Procedures in the Research Study:

You will be provided a fitness tracking device (e.g. "Fitbit") if you do not currectly have a model that is compatible with the study. You will be responsible for wearing the tracker every day and keeping it charged. We ask that you charge the Fitbit during the day (not overnight). The Fitbit we provide is waterproof and may be worn in the shower, bath, or pool, but this is not necessary for the purposes of the study. On a regular basis, data will be downloaded from your device over the "web" so you must have access to a bluetooth enabled device (i.e. phone or computer) and download the Fitbit app onto that device. We will walk you through this procedure. The data will be collected on Fitbit's servers and accessed by the UTSA research team. The data will consist of activity measures such as steps walked, blood pressure, heartrate, blood oxygen level, and sleep. After being received from Fitbit, all fitness tracking data is automatically anonymized and stored on a secure server at UTSA to prevent any unauthorized parties from gaining access to or using the data to identify you. Likewise, data collected from you by other means will also be anonymized and securely stored.

For volunteers recruited through our clinical collaborations, we may request access to your medical records from our clinical partners (such as cognitive test results, apnea/hypopnea index, etc.)

1) Activity tracking: After signing a waiver to give researchers access to activity data, you may be provided with a fitness tracking device (e.g. "Fitbit") which you agree to continuously wear and keep charged. You agree not to sell, give away or otherwise transfer this device. We ask that you charge the Fitbit during the day and wear the Fitbit anytime it is not charging. On a regular basis, data will be downloaded from your device over the web. This information will consist of behavioral measures such as steps walked, blood pressure, heartrate, blood oxygen level, and sleep. The data will be collected from FitBit's servers and accessed by the UTSA research team. After being received from FitBit, all fitness tracking data is automatically anonymized and stored on a secure server to prevent any unauthorized parties from gaining access to or using the data to identify you. If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted. A Fitbit tracker will be provided to be used over the course of the study, and if you agree to allow us long-term monitoring of your physical activity, you may keep it after the completion of the study.
1) Activity tracking
2) Blood sample: This study will generally involve one visit every 6 months in which 1-3 tubes of blood will be obtained for research purposes. Subjects included in an intervention will be required to give blood before, during, and after the intervention is complete. Blood sample for adults weighing 110lbs will not exceed 550mL in an 8 week period and blood draw will not occur more frequently than 2 times per week. For adult subjects less than 110lbs, the amount drawn will not exceed the lesser of 50mL or 3mL/kg in an 8 week period and blood draw will not occur more frequently than 2 times per week. Blood will be collected from a participating lab. Participants will be assigned a numbered identifier, and all blood samples will be marked with that number only. Blood samples will be stored at UTSA, or with a collaborator pending testing. All unused blood will be stored at UTSA indefinitely or disposed of. If a participant wishes to withdraw from the study, we may request to keep specimens collected up until the point participant withdrew. The participant may elect to allow us to keep the specimen and use it for research purposes, or they may ask for it to be disposed of.
2) Blood sample
3) Non-invasive imaging: This study will use fMRI, PET and OCT scans. This data is important to chart how the biology of the brain is changing over time. All scans will be done at collaborating research sites for research purposes only. Images and scans will be marked with the participant's numbered identifier only. Digital images will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep images collected up until the point participant withdrew. The participant may elect to allow us to keep the images and use it for research purposes, or they may ask for it to be disposed of.
3) Non-invasive imaging
4) Polysomnography(PSG): This study will use PSG (sleep study) to detect sleep stages and other characteristics of sleep. This data will be used to detect EEG and sleep architecture. PSG will be performed at collaborating research sites for research purposes only. Subjects who agree to wear a tracking device during a polysomnograph will release all sleep study data to the Quantu research team. PSG will be marked with the participants numbered identifier only. PSG data will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep PSG data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be disposed of.
4) Polysomnography(PSG)
5) Cognitive Testing: This study will use cognitive testing via website/app to establish baseline cognitive function and monitor changes in cognitive ability over the course of the study.
5) Cognitive Testing
6) One night PSG + Fitbit: Subjects who are already having a PSG procedure can opt to wear a Fitbit during the night of the procedure for comparison studies. The Fitbit will be returned to sleep lab personnel after the completion of the sleep study. Subjects are welcome to join the long term study if they choose. Subjects who agree to wear a tracking device during a polysomnograph will release all sleep study data to the Quantu research team. PSG will be marked with the participants numbered identifier only. PSG data will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep PSG data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be disposed of.
6) One night PSG + Fitbit
7) Cognitive Training Intervention: You will be asked to do a series of cognitive training exercises via app or remote learning for 6 weeks - 6 months. You will be asked to give blood prior to the start of the intervention, during the intervention, and after the intervention. After the intervention is completed, you will continue to be racked via Fitbit tracker and 6 month blood draws (from the data of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes. or they may ask for it to be deleted.
7) Cognitive Training Intervention
8) Exercise Intervention: You will be asked to increase your activity levels for 6 weeks - 6 months. You will either be provided with a goal (i.e. take 10,000 steps per day) that will increase your activity level by 5-30% or be required to take an online fitness class provided by the Quantu project. You will be asked to give blood prior to the start of the intervention and after the completion of the intervention. After the intervention is completed, you will continue to be tracked vid Fitbit tracker and 6 month blood draws (from the data of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted.
8) Exercise Intervention
9) UV Light Exposure Intervention: You will be given Luminette UV light therapy glasses which they will use in the morning for 30 minutes each day for 6 weeks - 6 months. You will give blood prior to the start of the intervention and after the completion of the intervention. After the intervention is completed, You will continue to be tracked via FitBit tracker and 6 month blood draws (from the date of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted.
9) UV Light Exposure Intervention
10) DNA Testing:
10) DNA Testing
You will be asked to perform several tests of olfaction (your capacity to distinguish odors). These noninvasive tests may be self-administered and involve distinguishing between different odors included in a disposable kit. You may be asked to self-score these tests and report your scores to the Quantu research team or you may be asked to submit your responses directly via an online form or application. All test scores are anonymized for reporting, and you may not receive your test scores.
Olfactory Testing
Due to the role viruses and bacteria may play in long-term neurovasculature, cardiac and cognitive health, you may be asked about the results of related tests (i.e. SARS-CoV-2 (COVID-19)). Additionally, you may opt to have a viral or antibody test performed by a clinical facility, in which case the results of this test may be reported to the Quantu research team. All test results are anonymized for reporting and are not used for clinical diagnosis or treatment.
Results of infectious disease testing
This will allow us to access activity data prior to you being enrolled in the study. (optional)
Prior activity tracker data
Fifth Participant's Name

First Name*

Last Name*

Phone*
Fifth Participant's Date of Birth*
Fifth Participant's Role in the Research Study

Research Procedures in the Research Study:

You will be provided a fitness tracking device (e.g. "Fitbit") if you do not currectly have a model that is compatible with the study. You will be responsible for wearing the tracker every day and keeping it charged. We ask that you charge the Fitbit during the day (not overnight). The Fitbit we provide is waterproof and may be worn in the shower, bath, or pool, but this is not necessary for the purposes of the study. On a regular basis, data will be downloaded from your device over the "web" so you must have access to a bluetooth enabled device (i.e. phone or computer) and download the Fitbit app onto that device. We will walk you through this procedure. The data will be collected on Fitbit's servers and accessed by the UTSA research team. The data will consist of activity measures such as steps walked, blood pressure, heartrate, blood oxygen level, and sleep. After being received from Fitbit, all fitness tracking data is automatically anonymized and stored on a secure server at UTSA to prevent any unauthorized parties from gaining access to or using the data to identify you. Likewise, data collected from you by other means will also be anonymized and securely stored.

For volunteers recruited through our clinical collaborations, we may request access to your medical records from our clinical partners (such as cognitive test results, apnea/hypopnea index, etc.)

1) Activity tracking: After signing a waiver to give researchers access to activity data, you may be provided with a fitness tracking device (e.g. "Fitbit") which you agree to continuously wear and keep charged. You agree not to sell, give away or otherwise transfer this device. We ask that you charge the Fitbit during the day and wear the Fitbit anytime it is not charging. On a regular basis, data will be downloaded from your device over the web. This information will consist of behavioral measures such as steps walked, blood pressure, heartrate, blood oxygen level, and sleep. The data will be collected from FitBit's servers and accessed by the UTSA research team. After being received from FitBit, all fitness tracking data is automatically anonymized and stored on a secure server to prevent any unauthorized parties from gaining access to or using the data to identify you. If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted. A Fitbit tracker will be provided to be used over the course of the study, and if you agree to allow us long-term monitoring of your physical activity, you may keep it after the completion of the study.
1) Activity tracking
2) Blood sample: This study will generally involve one visit every 6 months in which 1-3 tubes of blood will be obtained for research purposes. Subjects included in an intervention will be required to give blood before, during, and after the intervention is complete. Blood sample for adults weighing 110lbs will not exceed 550mL in an 8 week period and blood draw will not occur more frequently than 2 times per week. For adult subjects less than 110lbs, the amount drawn will not exceed the lesser of 50mL or 3mL/kg in an 8 week period and blood draw will not occur more frequently than 2 times per week. Blood will be collected from a participating lab. Participants will be assigned a numbered identifier, and all blood samples will be marked with that number only. Blood samples will be stored at UTSA, or with a collaborator pending testing. All unused blood will be stored at UTSA indefinitely or disposed of. If a participant wishes to withdraw from the study, we may request to keep specimens collected up until the point participant withdrew. The participant may elect to allow us to keep the specimen and use it for research purposes, or they may ask for it to be disposed of.
2) Blood sample
3) Non-invasive imaging: This study will use fMRI, PET and OCT scans. This data is important to chart how the biology of the brain is changing over time. All scans will be done at collaborating research sites for research purposes only. Images and scans will be marked with the participant's numbered identifier only. Digital images will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep images collected up until the point participant withdrew. The participant may elect to allow us to keep the images and use it for research purposes, or they may ask for it to be disposed of.
3) Non-invasive imaging
4) Polysomnography(PSG): This study will use PSG (sleep study) to detect sleep stages and other characteristics of sleep. This data will be used to detect EEG and sleep architecture. PSG will be performed at collaborating research sites for research purposes only. Subjects who agree to wear a tracking device during a polysomnograph will release all sleep study data to the Quantu research team. PSG will be marked with the participants numbered identifier only. PSG data will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep PSG data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be disposed of.
4) Polysomnography(PSG)
5) Cognitive Testing: This study will use cognitive testing via website/app to establish baseline cognitive function and monitor changes in cognitive ability over the course of the study.
5) Cognitive Testing
6) One night PSG + Fitbit: Subjects who are already having a PSG procedure can opt to wear a Fitbit during the night of the procedure for comparison studies. The Fitbit will be returned to sleep lab personnel after the completion of the sleep study. Subjects are welcome to join the long term study if they choose. Subjects who agree to wear a tracking device during a polysomnograph will release all sleep study data to the Quantu research team. PSG will be marked with the participants numbered identifier only. PSG data will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep PSG data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be disposed of.
6) One night PSG + Fitbit
7) Cognitive Training Intervention: You will be asked to do a series of cognitive training exercises via app or remote learning for 6 weeks - 6 months. You will be asked to give blood prior to the start of the intervention, during the intervention, and after the intervention. After the intervention is completed, you will continue to be racked via Fitbit tracker and 6 month blood draws (from the data of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes. or they may ask for it to be deleted.
7) Cognitive Training Intervention
8) Exercise Intervention: You will be asked to increase your activity levels for 6 weeks - 6 months. You will either be provided with a goal (i.e. take 10,000 steps per day) that will increase your activity level by 5-30% or be required to take an online fitness class provided by the Quantu project. You will be asked to give blood prior to the start of the intervention and after the completion of the intervention. After the intervention is completed, you will continue to be tracked vid Fitbit tracker and 6 month blood draws (from the data of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted.
8) Exercise Intervention
9) UV Light Exposure Intervention: You will be given Luminette UV light therapy glasses which they will use in the morning for 30 minutes each day for 6 weeks - 6 months. You will give blood prior to the start of the intervention and after the completion of the intervention. After the intervention is completed, You will continue to be tracked via FitBit tracker and 6 month blood draws (from the date of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted.
9) UV Light Exposure Intervention
10) DNA Testing:
10) DNA Testing
You will be asked to perform several tests of olfaction (your capacity to distinguish odors). These noninvasive tests may be self-administered and involve distinguishing between different odors included in a disposable kit. You may be asked to self-score these tests and report your scores to the Quantu research team or you may be asked to submit your responses directly via an online form or application. All test scores are anonymized for reporting, and you may not receive your test scores.
Olfactory Testing
Due to the role viruses and bacteria may play in long-term neurovasculature, cardiac and cognitive health, you may be asked about the results of related tests (i.e. SARS-CoV-2 (COVID-19)). Additionally, you may opt to have a viral or antibody test performed by a clinical facility, in which case the results of this test may be reported to the Quantu research team. All test results are anonymized for reporting and are not used for clinical diagnosis or treatment.
Results of infectious disease testing
This will allow us to access activity data prior to you being enrolled in the study. (optional)
Prior activity tracker data
Sixth Participant's Name

First Name*

Last Name*

Phone*
Sixth Participant's Date of Birth*
Sixth Participant's Role in the Research Study

Research Procedures in the Research Study:

You will be provided a fitness tracking device (e.g. "Fitbit") if you do not currectly have a model that is compatible with the study. You will be responsible for wearing the tracker every day and keeping it charged. We ask that you charge the Fitbit during the day (not overnight). The Fitbit we provide is waterproof and may be worn in the shower, bath, or pool, but this is not necessary for the purposes of the study. On a regular basis, data will be downloaded from your device over the "web" so you must have access to a bluetooth enabled device (i.e. phone or computer) and download the Fitbit app onto that device. We will walk you through this procedure. The data will be collected on Fitbit's servers and accessed by the UTSA research team. The data will consist of activity measures such as steps walked, blood pressure, heartrate, blood oxygen level, and sleep. After being received from Fitbit, all fitness tracking data is automatically anonymized and stored on a secure server at UTSA to prevent any unauthorized parties from gaining access to or using the data to identify you. Likewise, data collected from you by other means will also be anonymized and securely stored.

For volunteers recruited through our clinical collaborations, we may request access to your medical records from our clinical partners (such as cognitive test results, apnea/hypopnea index, etc.)

1) Activity tracking: After signing a waiver to give researchers access to activity data, you may be provided with a fitness tracking device (e.g. "Fitbit") which you agree to continuously wear and keep charged. You agree not to sell, give away or otherwise transfer this device. We ask that you charge the Fitbit during the day and wear the Fitbit anytime it is not charging. On a regular basis, data will be downloaded from your device over the web. This information will consist of behavioral measures such as steps walked, blood pressure, heartrate, blood oxygen level, and sleep. The data will be collected from FitBit's servers and accessed by the UTSA research team. After being received from FitBit, all fitness tracking data is automatically anonymized and stored on a secure server to prevent any unauthorized parties from gaining access to or using the data to identify you. If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted. A Fitbit tracker will be provided to be used over the course of the study, and if you agree to allow us long-term monitoring of your physical activity, you may keep it after the completion of the study.
1) Activity tracking
2) Blood sample: This study will generally involve one visit every 6 months in which 1-3 tubes of blood will be obtained for research purposes. Subjects included in an intervention will be required to give blood before, during, and after the intervention is complete. Blood sample for adults weighing 110lbs will not exceed 550mL in an 8 week period and blood draw will not occur more frequently than 2 times per week. For adult subjects less than 110lbs, the amount drawn will not exceed the lesser of 50mL or 3mL/kg in an 8 week period and blood draw will not occur more frequently than 2 times per week. Blood will be collected from a participating lab. Participants will be assigned a numbered identifier, and all blood samples will be marked with that number only. Blood samples will be stored at UTSA, or with a collaborator pending testing. All unused blood will be stored at UTSA indefinitely or disposed of. If a participant wishes to withdraw from the study, we may request to keep specimens collected up until the point participant withdrew. The participant may elect to allow us to keep the specimen and use it for research purposes, or they may ask for it to be disposed of.
2) Blood sample
3) Non-invasive imaging: This study will use fMRI, PET and OCT scans. This data is important to chart how the biology of the brain is changing over time. All scans will be done at collaborating research sites for research purposes only. Images and scans will be marked with the participant's numbered identifier only. Digital images will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep images collected up until the point participant withdrew. The participant may elect to allow us to keep the images and use it for research purposes, or they may ask for it to be disposed of.
3) Non-invasive imaging
4) Polysomnography(PSG): This study will use PSG (sleep study) to detect sleep stages and other characteristics of sleep. This data will be used to detect EEG and sleep architecture. PSG will be performed at collaborating research sites for research purposes only. Subjects who agree to wear a tracking device during a polysomnograph will release all sleep study data to the Quantu research team. PSG will be marked with the participants numbered identifier only. PSG data will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep PSG data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be disposed of.
4) Polysomnography(PSG)
5) Cognitive Testing: This study will use cognitive testing via website/app to establish baseline cognitive function and monitor changes in cognitive ability over the course of the study.
5) Cognitive Testing
6) One night PSG + Fitbit: Subjects who are already having a PSG procedure can opt to wear a Fitbit during the night of the procedure for comparison studies. The Fitbit will be returned to sleep lab personnel after the completion of the sleep study. Subjects are welcome to join the long term study if they choose. Subjects who agree to wear a tracking device during a polysomnograph will release all sleep study data to the Quantu research team. PSG will be marked with the participants numbered identifier only. PSG data will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep PSG data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be disposed of.
6) One night PSG + Fitbit
7) Cognitive Training Intervention: You will be asked to do a series of cognitive training exercises via app or remote learning for 6 weeks - 6 months. You will be asked to give blood prior to the start of the intervention, during the intervention, and after the intervention. After the intervention is completed, you will continue to be racked via Fitbit tracker and 6 month blood draws (from the data of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes. or they may ask for it to be deleted.
7) Cognitive Training Intervention
8) Exercise Intervention: You will be asked to increase your activity levels for 6 weeks - 6 months. You will either be provided with a goal (i.e. take 10,000 steps per day) that will increase your activity level by 5-30% or be required to take an online fitness class provided by the Quantu project. You will be asked to give blood prior to the start of the intervention and after the completion of the intervention. After the intervention is completed, you will continue to be tracked vid Fitbit tracker and 6 month blood draws (from the data of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted.
8) Exercise Intervention
9) UV Light Exposure Intervention: You will be given Luminette UV light therapy glasses which they will use in the morning for 30 minutes each day for 6 weeks - 6 months. You will give blood prior to the start of the intervention and after the completion of the intervention. After the intervention is completed, You will continue to be tracked via FitBit tracker and 6 month blood draws (from the date of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted.
9) UV Light Exposure Intervention
10) DNA Testing:
10) DNA Testing
You will be asked to perform several tests of olfaction (your capacity to distinguish odors). These noninvasive tests may be self-administered and involve distinguishing between different odors included in a disposable kit. You may be asked to self-score these tests and report your scores to the Quantu research team or you may be asked to submit your responses directly via an online form or application. All test scores are anonymized for reporting, and you may not receive your test scores.
Olfactory Testing
Due to the role viruses and bacteria may play in long-term neurovasculature, cardiac and cognitive health, you may be asked about the results of related tests (i.e. SARS-CoV-2 (COVID-19)). Additionally, you may opt to have a viral or antibody test performed by a clinical facility, in which case the results of this test may be reported to the Quantu research team. All test results are anonymized for reporting and are not used for clinical diagnosis or treatment.
Results of infectious disease testing
This will allow us to access activity data prior to you being enrolled in the study. (optional)
Prior activity tracker data
Seventh Participant's Name

First Name*

Last Name*

Phone*
Seventh Participant's Date of Birth*
Seventh Participant's Role in the Research Study

Research Procedures in the Research Study:

You will be provided a fitness tracking device (e.g. "Fitbit") if you do not currectly have a model that is compatible with the study. You will be responsible for wearing the tracker every day and keeping it charged. We ask that you charge the Fitbit during the day (not overnight). The Fitbit we provide is waterproof and may be worn in the shower, bath, or pool, but this is not necessary for the purposes of the study. On a regular basis, data will be downloaded from your device over the "web" so you must have access to a bluetooth enabled device (i.e. phone or computer) and download the Fitbit app onto that device. We will walk you through this procedure. The data will be collected on Fitbit's servers and accessed by the UTSA research team. The data will consist of activity measures such as steps walked, blood pressure, heartrate, blood oxygen level, and sleep. After being received from Fitbit, all fitness tracking data is automatically anonymized and stored on a secure server at UTSA to prevent any unauthorized parties from gaining access to or using the data to identify you. Likewise, data collected from you by other means will also be anonymized and securely stored.

For volunteers recruited through our clinical collaborations, we may request access to your medical records from our clinical partners (such as cognitive test results, apnea/hypopnea index, etc.)

1) Activity tracking: After signing a waiver to give researchers access to activity data, you may be provided with a fitness tracking device (e.g. "Fitbit") which you agree to continuously wear and keep charged. You agree not to sell, give away or otherwise transfer this device. We ask that you charge the Fitbit during the day and wear the Fitbit anytime it is not charging. On a regular basis, data will be downloaded from your device over the web. This information will consist of behavioral measures such as steps walked, blood pressure, heartrate, blood oxygen level, and sleep. The data will be collected from FitBit's servers and accessed by the UTSA research team. After being received from FitBit, all fitness tracking data is automatically anonymized and stored on a secure server to prevent any unauthorized parties from gaining access to or using the data to identify you. If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted. A Fitbit tracker will be provided to be used over the course of the study, and if you agree to allow us long-term monitoring of your physical activity, you may keep it after the completion of the study.
1) Activity tracking
2) Blood sample: This study will generally involve one visit every 6 months in which 1-3 tubes of blood will be obtained for research purposes. Subjects included in an intervention will be required to give blood before, during, and after the intervention is complete. Blood sample for adults weighing 110lbs will not exceed 550mL in an 8 week period and blood draw will not occur more frequently than 2 times per week. For adult subjects less than 110lbs, the amount drawn will not exceed the lesser of 50mL or 3mL/kg in an 8 week period and blood draw will not occur more frequently than 2 times per week. Blood will be collected from a participating lab. Participants will be assigned a numbered identifier, and all blood samples will be marked with that number only. Blood samples will be stored at UTSA, or with a collaborator pending testing. All unused blood will be stored at UTSA indefinitely or disposed of. If a participant wishes to withdraw from the study, we may request to keep specimens collected up until the point participant withdrew. The participant may elect to allow us to keep the specimen and use it for research purposes, or they may ask for it to be disposed of.
2) Blood sample
3) Non-invasive imaging: This study will use fMRI, PET and OCT scans. This data is important to chart how the biology of the brain is changing over time. All scans will be done at collaborating research sites for research purposes only. Images and scans will be marked with the participant's numbered identifier only. Digital images will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep images collected up until the point participant withdrew. The participant may elect to allow us to keep the images and use it for research purposes, or they may ask for it to be disposed of.
3) Non-invasive imaging
4) Polysomnography(PSG): This study will use PSG (sleep study) to detect sleep stages and other characteristics of sleep. This data will be used to detect EEG and sleep architecture. PSG will be performed at collaborating research sites for research purposes only. Subjects who agree to wear a tracking device during a polysomnograph will release all sleep study data to the Quantu research team. PSG will be marked with the participants numbered identifier only. PSG data will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep PSG data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be disposed of.
4) Polysomnography(PSG)
5) Cognitive Testing: This study will use cognitive testing via website/app to establish baseline cognitive function and monitor changes in cognitive ability over the course of the study.
5) Cognitive Testing
6) One night PSG + Fitbit: Subjects who are already having a PSG procedure can opt to wear a Fitbit during the night of the procedure for comparison studies. The Fitbit will be returned to sleep lab personnel after the completion of the sleep study. Subjects are welcome to join the long term study if they choose. Subjects who agree to wear a tracking device during a polysomnograph will release all sleep study data to the Quantu research team. PSG will be marked with the participants numbered identifier only. PSG data will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep PSG data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be disposed of.
6) One night PSG + Fitbit
7) Cognitive Training Intervention: You will be asked to do a series of cognitive training exercises via app or remote learning for 6 weeks - 6 months. You will be asked to give blood prior to the start of the intervention, during the intervention, and after the intervention. After the intervention is completed, you will continue to be racked via Fitbit tracker and 6 month blood draws (from the data of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes. or they may ask for it to be deleted.
7) Cognitive Training Intervention
8) Exercise Intervention: You will be asked to increase your activity levels for 6 weeks - 6 months. You will either be provided with a goal (i.e. take 10,000 steps per day) that will increase your activity level by 5-30% or be required to take an online fitness class provided by the Quantu project. You will be asked to give blood prior to the start of the intervention and after the completion of the intervention. After the intervention is completed, you will continue to be tracked vid Fitbit tracker and 6 month blood draws (from the data of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted.
8) Exercise Intervention
9) UV Light Exposure Intervention: You will be given Luminette UV light therapy glasses which they will use in the morning for 30 minutes each day for 6 weeks - 6 months. You will give blood prior to the start of the intervention and after the completion of the intervention. After the intervention is completed, You will continue to be tracked via FitBit tracker and 6 month blood draws (from the date of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted.
9) UV Light Exposure Intervention
10) DNA Testing:
10) DNA Testing
You will be asked to perform several tests of olfaction (your capacity to distinguish odors). These noninvasive tests may be self-administered and involve distinguishing between different odors included in a disposable kit. You may be asked to self-score these tests and report your scores to the Quantu research team or you may be asked to submit your responses directly via an online form or application. All test scores are anonymized for reporting, and you may not receive your test scores.
Olfactory Testing
Due to the role viruses and bacteria may play in long-term neurovasculature, cardiac and cognitive health, you may be asked about the results of related tests (i.e. SARS-CoV-2 (COVID-19)). Additionally, you may opt to have a viral or antibody test performed by a clinical facility, in which case the results of this test may be reported to the Quantu research team. All test results are anonymized for reporting and are not used for clinical diagnosis or treatment.
Results of infectious disease testing
This will allow us to access activity data prior to you being enrolled in the study. (optional)
Prior activity tracker data
Eighth Participant's Name

First Name*

Last Name*

Phone*
Eighth Participant's Date of Birth*
Eighth Participant's Role in the Research Study

Research Procedures in the Research Study:

You will be provided a fitness tracking device (e.g. "Fitbit") if you do not currectly have a model that is compatible with the study. You will be responsible for wearing the tracker every day and keeping it charged. We ask that you charge the Fitbit during the day (not overnight). The Fitbit we provide is waterproof and may be worn in the shower, bath, or pool, but this is not necessary for the purposes of the study. On a regular basis, data will be downloaded from your device over the "web" so you must have access to a bluetooth enabled device (i.e. phone or computer) and download the Fitbit app onto that device. We will walk you through this procedure. The data will be collected on Fitbit's servers and accessed by the UTSA research team. The data will consist of activity measures such as steps walked, blood pressure, heartrate, blood oxygen level, and sleep. After being received from Fitbit, all fitness tracking data is automatically anonymized and stored on a secure server at UTSA to prevent any unauthorized parties from gaining access to or using the data to identify you. Likewise, data collected from you by other means will also be anonymized and securely stored.

For volunteers recruited through our clinical collaborations, we may request access to your medical records from our clinical partners (such as cognitive test results, apnea/hypopnea index, etc.)

1) Activity tracking: After signing a waiver to give researchers access to activity data, you may be provided with a fitness tracking device (e.g. "Fitbit") which you agree to continuously wear and keep charged. You agree not to sell, give away or otherwise transfer this device. We ask that you charge the Fitbit during the day and wear the Fitbit anytime it is not charging. On a regular basis, data will be downloaded from your device over the web. This information will consist of behavioral measures such as steps walked, blood pressure, heartrate, blood oxygen level, and sleep. The data will be collected from FitBit's servers and accessed by the UTSA research team. After being received from FitBit, all fitness tracking data is automatically anonymized and stored on a secure server to prevent any unauthorized parties from gaining access to or using the data to identify you. If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted. A Fitbit tracker will be provided to be used over the course of the study, and if you agree to allow us long-term monitoring of your physical activity, you may keep it after the completion of the study.
1) Activity tracking
2) Blood sample: This study will generally involve one visit every 6 months in which 1-3 tubes of blood will be obtained for research purposes. Subjects included in an intervention will be required to give blood before, during, and after the intervention is complete. Blood sample for adults weighing 110lbs will not exceed 550mL in an 8 week period and blood draw will not occur more frequently than 2 times per week. For adult subjects less than 110lbs, the amount drawn will not exceed the lesser of 50mL or 3mL/kg in an 8 week period and blood draw will not occur more frequently than 2 times per week. Blood will be collected from a participating lab. Participants will be assigned a numbered identifier, and all blood samples will be marked with that number only. Blood samples will be stored at UTSA, or with a collaborator pending testing. All unused blood will be stored at UTSA indefinitely or disposed of. If a participant wishes to withdraw from the study, we may request to keep specimens collected up until the point participant withdrew. The participant may elect to allow us to keep the specimen and use it for research purposes, or they may ask for it to be disposed of.
2) Blood sample
3) Non-invasive imaging: This study will use fMRI, PET and OCT scans. This data is important to chart how the biology of the brain is changing over time. All scans will be done at collaborating research sites for research purposes only. Images and scans will be marked with the participant's numbered identifier only. Digital images will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep images collected up until the point participant withdrew. The participant may elect to allow us to keep the images and use it for research purposes, or they may ask for it to be disposed of.
3) Non-invasive imaging
4) Polysomnography(PSG): This study will use PSG (sleep study) to detect sleep stages and other characteristics of sleep. This data will be used to detect EEG and sleep architecture. PSG will be performed at collaborating research sites for research purposes only. Subjects who agree to wear a tracking device during a polysomnograph will release all sleep study data to the Quantu research team. PSG will be marked with the participants numbered identifier only. PSG data will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep PSG data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be disposed of.
4) Polysomnography(PSG)
5) Cognitive Testing: This study will use cognitive testing via website/app to establish baseline cognitive function and monitor changes in cognitive ability over the course of the study.
5) Cognitive Testing
6) One night PSG + Fitbit: Subjects who are already having a PSG procedure can opt to wear a Fitbit during the night of the procedure for comparison studies. The Fitbit will be returned to sleep lab personnel after the completion of the sleep study. Subjects are welcome to join the long term study if they choose. Subjects who agree to wear a tracking device during a polysomnograph will release all sleep study data to the Quantu research team. PSG will be marked with the participants numbered identifier only. PSG data will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep PSG data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be disposed of.
6) One night PSG + Fitbit
7) Cognitive Training Intervention: You will be asked to do a series of cognitive training exercises via app or remote learning for 6 weeks - 6 months. You will be asked to give blood prior to the start of the intervention, during the intervention, and after the intervention. After the intervention is completed, you will continue to be racked via Fitbit tracker and 6 month blood draws (from the data of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes. or they may ask for it to be deleted.
7) Cognitive Training Intervention
8) Exercise Intervention: You will be asked to increase your activity levels for 6 weeks - 6 months. You will either be provided with a goal (i.e. take 10,000 steps per day) that will increase your activity level by 5-30% or be required to take an online fitness class provided by the Quantu project. You will be asked to give blood prior to the start of the intervention and after the completion of the intervention. After the intervention is completed, you will continue to be tracked vid Fitbit tracker and 6 month blood draws (from the data of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted.
8) Exercise Intervention
9) UV Light Exposure Intervention: You will be given Luminette UV light therapy glasses which they will use in the morning for 30 minutes each day for 6 weeks - 6 months. You will give blood prior to the start of the intervention and after the completion of the intervention. After the intervention is completed, You will continue to be tracked via FitBit tracker and 6 month blood draws (from the date of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted.
9) UV Light Exposure Intervention
10) DNA Testing:
10) DNA Testing
You will be asked to perform several tests of olfaction (your capacity to distinguish odors). These noninvasive tests may be self-administered and involve distinguishing between different odors included in a disposable kit. You may be asked to self-score these tests and report your scores to the Quantu research team or you may be asked to submit your responses directly via an online form or application. All test scores are anonymized for reporting, and you may not receive your test scores.
Olfactory Testing
Due to the role viruses and bacteria may play in long-term neurovasculature, cardiac and cognitive health, you may be asked about the results of related tests (i.e. SARS-CoV-2 (COVID-19)). Additionally, you may opt to have a viral or antibody test performed by a clinical facility, in which case the results of this test may be reported to the Quantu research team. All test results are anonymized for reporting and are not used for clinical diagnosis or treatment.
Results of infectious disease testing
This will allow us to access activity data prior to you being enrolled in the study. (optional)
Prior activity tracker data
Ninth Participant's Name

First Name*

Last Name*

Phone*
Ninth Participant's Date of Birth*
Ninth Participant's Role in the Research Study

Research Procedures in the Research Study:

You will be provided a fitness tracking device (e.g. "Fitbit") if you do not currectly have a model that is compatible with the study. You will be responsible for wearing the tracker every day and keeping it charged. We ask that you charge the Fitbit during the day (not overnight). The Fitbit we provide is waterproof and may be worn in the shower, bath, or pool, but this is not necessary for the purposes of the study. On a regular basis, data will be downloaded from your device over the "web" so you must have access to a bluetooth enabled device (i.e. phone or computer) and download the Fitbit app onto that device. We will walk you through this procedure. The data will be collected on Fitbit's servers and accessed by the UTSA research team. The data will consist of activity measures such as steps walked, blood pressure, heartrate, blood oxygen level, and sleep. After being received from Fitbit, all fitness tracking data is automatically anonymized and stored on a secure server at UTSA to prevent any unauthorized parties from gaining access to or using the data to identify you. Likewise, data collected from you by other means will also be anonymized and securely stored.

For volunteers recruited through our clinical collaborations, we may request access to your medical records from our clinical partners (such as cognitive test results, apnea/hypopnea index, etc.)

1) Activity tracking: After signing a waiver to give researchers access to activity data, you may be provided with a fitness tracking device (e.g. "Fitbit") which you agree to continuously wear and keep charged. You agree not to sell, give away or otherwise transfer this device. We ask that you charge the Fitbit during the day and wear the Fitbit anytime it is not charging. On a regular basis, data will be downloaded from your device over the web. This information will consist of behavioral measures such as steps walked, blood pressure, heartrate, blood oxygen level, and sleep. The data will be collected from FitBit's servers and accessed by the UTSA research team. After being received from FitBit, all fitness tracking data is automatically anonymized and stored on a secure server to prevent any unauthorized parties from gaining access to or using the data to identify you. If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted. A Fitbit tracker will be provided to be used over the course of the study, and if you agree to allow us long-term monitoring of your physical activity, you may keep it after the completion of the study.
1) Activity tracking
2) Blood sample: This study will generally involve one visit every 6 months in which 1-3 tubes of blood will be obtained for research purposes. Subjects included in an intervention will be required to give blood before, during, and after the intervention is complete. Blood sample for adults weighing 110lbs will not exceed 550mL in an 8 week period and blood draw will not occur more frequently than 2 times per week. For adult subjects less than 110lbs, the amount drawn will not exceed the lesser of 50mL or 3mL/kg in an 8 week period and blood draw will not occur more frequently than 2 times per week. Blood will be collected from a participating lab. Participants will be assigned a numbered identifier, and all blood samples will be marked with that number only. Blood samples will be stored at UTSA, or with a collaborator pending testing. All unused blood will be stored at UTSA indefinitely or disposed of. If a participant wishes to withdraw from the study, we may request to keep specimens collected up until the point participant withdrew. The participant may elect to allow us to keep the specimen and use it for research purposes, or they may ask for it to be disposed of.
2) Blood sample
3) Non-invasive imaging: This study will use fMRI, PET and OCT scans. This data is important to chart how the biology of the brain is changing over time. All scans will be done at collaborating research sites for research purposes only. Images and scans will be marked with the participant's numbered identifier only. Digital images will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep images collected up until the point participant withdrew. The participant may elect to allow us to keep the images and use it for research purposes, or they may ask for it to be disposed of.
3) Non-invasive imaging
4) Polysomnography(PSG): This study will use PSG (sleep study) to detect sleep stages and other characteristics of sleep. This data will be used to detect EEG and sleep architecture. PSG will be performed at collaborating research sites for research purposes only. Subjects who agree to wear a tracking device during a polysomnograph will release all sleep study data to the Quantu research team. PSG will be marked with the participants numbered identifier only. PSG data will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep PSG data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be disposed of.
4) Polysomnography(PSG)
5) Cognitive Testing: This study will use cognitive testing via website/app to establish baseline cognitive function and monitor changes in cognitive ability over the course of the study.
5) Cognitive Testing
6) One night PSG + Fitbit: Subjects who are already having a PSG procedure can opt to wear a Fitbit during the night of the procedure for comparison studies. The Fitbit will be returned to sleep lab personnel after the completion of the sleep study. Subjects are welcome to join the long term study if they choose. Subjects who agree to wear a tracking device during a polysomnograph will release all sleep study data to the Quantu research team. PSG will be marked with the participants numbered identifier only. PSG data will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep PSG data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be disposed of.
6) One night PSG + Fitbit
7) Cognitive Training Intervention: You will be asked to do a series of cognitive training exercises via app or remote learning for 6 weeks - 6 months. You will be asked to give blood prior to the start of the intervention, during the intervention, and after the intervention. After the intervention is completed, you will continue to be racked via Fitbit tracker and 6 month blood draws (from the data of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes. or they may ask for it to be deleted.
7) Cognitive Training Intervention
8) Exercise Intervention: You will be asked to increase your activity levels for 6 weeks - 6 months. You will either be provided with a goal (i.e. take 10,000 steps per day) that will increase your activity level by 5-30% or be required to take an online fitness class provided by the Quantu project. You will be asked to give blood prior to the start of the intervention and after the completion of the intervention. After the intervention is completed, you will continue to be tracked vid Fitbit tracker and 6 month blood draws (from the data of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted.
8) Exercise Intervention
9) UV Light Exposure Intervention: You will be given Luminette UV light therapy glasses which they will use in the morning for 30 minutes each day for 6 weeks - 6 months. You will give blood prior to the start of the intervention and after the completion of the intervention. After the intervention is completed, You will continue to be tracked via FitBit tracker and 6 month blood draws (from the date of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted.
9) UV Light Exposure Intervention
10) DNA Testing:
10) DNA Testing
You will be asked to perform several tests of olfaction (your capacity to distinguish odors). These noninvasive tests may be self-administered and involve distinguishing between different odors included in a disposable kit. You may be asked to self-score these tests and report your scores to the Quantu research team or you may be asked to submit your responses directly via an online form or application. All test scores are anonymized for reporting, and you may not receive your test scores.
Olfactory Testing
Due to the role viruses and bacteria may play in long-term neurovasculature, cardiac and cognitive health, you may be asked about the results of related tests (i.e. SARS-CoV-2 (COVID-19)). Additionally, you may opt to have a viral or antibody test performed by a clinical facility, in which case the results of this test may be reported to the Quantu research team. All test results are anonymized for reporting and are not used for clinical diagnosis or treatment.
Results of infectious disease testing
This will allow us to access activity data prior to you being enrolled in the study. (optional)
Prior activity tracker data
Tenth Participant's Name

First Name*

Last Name*

Phone*
Tenth Participant's Date of Birth*
Tenth Participant's Role in the Research Study

Research Procedures in the Research Study:

You will be provided a fitness tracking device (e.g. "Fitbit") if you do not currectly have a model that is compatible with the study. You will be responsible for wearing the tracker every day and keeping it charged. We ask that you charge the Fitbit during the day (not overnight). The Fitbit we provide is waterproof and may be worn in the shower, bath, or pool, but this is not necessary for the purposes of the study. On a regular basis, data will be downloaded from your device over the "web" so you must have access to a bluetooth enabled device (i.e. phone or computer) and download the Fitbit app onto that device. We will walk you through this procedure. The data will be collected on Fitbit's servers and accessed by the UTSA research team. The data will consist of activity measures such as steps walked, blood pressure, heartrate, blood oxygen level, and sleep. After being received from Fitbit, all fitness tracking data is automatically anonymized and stored on a secure server at UTSA to prevent any unauthorized parties from gaining access to or using the data to identify you. Likewise, data collected from you by other means will also be anonymized and securely stored.

For volunteers recruited through our clinical collaborations, we may request access to your medical records from our clinical partners (such as cognitive test results, apnea/hypopnea index, etc.)

1) Activity tracking: After signing a waiver to give researchers access to activity data, you may be provided with a fitness tracking device (e.g. "Fitbit") which you agree to continuously wear and keep charged. You agree not to sell, give away or otherwise transfer this device. We ask that you charge the Fitbit during the day and wear the Fitbit anytime it is not charging. On a regular basis, data will be downloaded from your device over the web. This information will consist of behavioral measures such as steps walked, blood pressure, heartrate, blood oxygen level, and sleep. The data will be collected from FitBit's servers and accessed by the UTSA research team. After being received from FitBit, all fitness tracking data is automatically anonymized and stored on a secure server to prevent any unauthorized parties from gaining access to or using the data to identify you. If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted. A Fitbit tracker will be provided to be used over the course of the study, and if you agree to allow us long-term monitoring of your physical activity, you may keep it after the completion of the study.
1) Activity tracking
2) Blood sample: This study will generally involve one visit every 6 months in which 1-3 tubes of blood will be obtained for research purposes. Subjects included in an intervention will be required to give blood before, during, and after the intervention is complete. Blood sample for adults weighing 110lbs will not exceed 550mL in an 8 week period and blood draw will not occur more frequently than 2 times per week. For adult subjects less than 110lbs, the amount drawn will not exceed the lesser of 50mL or 3mL/kg in an 8 week period and blood draw will not occur more frequently than 2 times per week. Blood will be collected from a participating lab. Participants will be assigned a numbered identifier, and all blood samples will be marked with that number only. Blood samples will be stored at UTSA, or with a collaborator pending testing. All unused blood will be stored at UTSA indefinitely or disposed of. If a participant wishes to withdraw from the study, we may request to keep specimens collected up until the point participant withdrew. The participant may elect to allow us to keep the specimen and use it for research purposes, or they may ask for it to be disposed of.
2) Blood sample
3) Non-invasive imaging: This study will use fMRI, PET and OCT scans. This data is important to chart how the biology of the brain is changing over time. All scans will be done at collaborating research sites for research purposes only. Images and scans will be marked with the participant's numbered identifier only. Digital images will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep images collected up until the point participant withdrew. The participant may elect to allow us to keep the images and use it for research purposes, or they may ask for it to be disposed of.
3) Non-invasive imaging
4) Polysomnography(PSG): This study will use PSG (sleep study) to detect sleep stages and other characteristics of sleep. This data will be used to detect EEG and sleep architecture. PSG will be performed at collaborating research sites for research purposes only. Subjects who agree to wear a tracking device during a polysomnograph will release all sleep study data to the Quantu research team. PSG will be marked with the participants numbered identifier only. PSG data will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep PSG data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be disposed of.
4) Polysomnography(PSG)
5) Cognitive Testing: This study will use cognitive testing via website/app to establish baseline cognitive function and monitor changes in cognitive ability over the course of the study.
5) Cognitive Testing
6) One night PSG + Fitbit: Subjects who are already having a PSG procedure can opt to wear a Fitbit during the night of the procedure for comparison studies. The Fitbit will be returned to sleep lab personnel after the completion of the sleep study. Subjects are welcome to join the long term study if they choose. Subjects who agree to wear a tracking device during a polysomnograph will release all sleep study data to the Quantu research team. PSG will be marked with the participants numbered identifier only. PSG data will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep PSG data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be disposed of.
6) One night PSG + Fitbit
7) Cognitive Training Intervention: You will be asked to do a series of cognitive training exercises via app or remote learning for 6 weeks - 6 months. You will be asked to give blood prior to the start of the intervention, during the intervention, and after the intervention. After the intervention is completed, you will continue to be racked via Fitbit tracker and 6 month blood draws (from the data of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes. or they may ask for it to be deleted.
7) Cognitive Training Intervention
8) Exercise Intervention: You will be asked to increase your activity levels for 6 weeks - 6 months. You will either be provided with a goal (i.e. take 10,000 steps per day) that will increase your activity level by 5-30% or be required to take an online fitness class provided by the Quantu project. You will be asked to give blood prior to the start of the intervention and after the completion of the intervention. After the intervention is completed, you will continue to be tracked vid Fitbit tracker and 6 month blood draws (from the data of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted.
8) Exercise Intervention
9) UV Light Exposure Intervention: You will be given Luminette UV light therapy glasses which they will use in the morning for 30 minutes each day for 6 weeks - 6 months. You will give blood prior to the start of the intervention and after the completion of the intervention. After the intervention is completed, You will continue to be tracked via FitBit tracker and 6 month blood draws (from the date of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted.
9) UV Light Exposure Intervention
10) DNA Testing:
10) DNA Testing
You will be asked to perform several tests of olfaction (your capacity to distinguish odors). These noninvasive tests may be self-administered and involve distinguishing between different odors included in a disposable kit. You may be asked to self-score these tests and report your scores to the Quantu research team or you may be asked to submit your responses directly via an online form or application. All test scores are anonymized for reporting, and you may not receive your test scores.
Olfactory Testing
Due to the role viruses and bacteria may play in long-term neurovasculature, cardiac and cognitive health, you may be asked about the results of related tests (i.e. SARS-CoV-2 (COVID-19)). Additionally, you may opt to have a viral or antibody test performed by a clinical facility, in which case the results of this test may be reported to the Quantu research team. All test results are anonymized for reporting and are not used for clinical diagnosis or treatment.
Results of infectious disease testing
This will allow us to access activity data prior to you being enrolled in the study. (optional)
Prior activity tracker data
Participant's Address
Address Line 1:
Street address, P.O. box, company name, c/o
Address Line 2:
Apartment, suite, unit, building, floor, etc.
Country:
City:
State/Province:
Zip/Postal:
Parent or Guardian's Email Address

Email
A signed copy of this waiver will be sent to the email address you provide.
Parent(s) or court-appointed legal guardian(s) must sign for any participating minor (those under 18 years of age) and agree that they and the minor are subject to all the terms of this document, as set forth above.
Parent or Guardian's Name

First Name*

Last Name*

Phone*
Parent or Guardian's Date of Birth*
Parent or Guardian's Role in the Research Study

Research Procedures in the Research Study:

You will be provided a fitness tracking device (e.g. "Fitbit") if you do not currectly have a model that is compatible with the study. You will be responsible for wearing the tracker every day and keeping it charged. We ask that you charge the Fitbit during the day (not overnight). The Fitbit we provide is waterproof and may be worn in the shower, bath, or pool, but this is not necessary for the purposes of the study. On a regular basis, data will be downloaded from your device over the "web" so you must have access to a bluetooth enabled device (i.e. phone or computer) and download the Fitbit app onto that device. We will walk you through this procedure. The data will be collected on Fitbit's servers and accessed by the UTSA research team. The data will consist of activity measures such as steps walked, blood pressure, heartrate, blood oxygen level, and sleep. After being received from Fitbit, all fitness tracking data is automatically anonymized and stored on a secure server at UTSA to prevent any unauthorized parties from gaining access to or using the data to identify you. Likewise, data collected from you by other means will also be anonymized and securely stored.

For volunteers recruited through our clinical collaborations, we may request access to your medical records from our clinical partners (such as cognitive test results, apnea/hypopnea index, etc.)

1) Activity tracking: After signing a waiver to give researchers access to activity data, you may be provided with a fitness tracking device (e.g. "Fitbit") which you agree to continuously wear and keep charged. You agree not to sell, give away or otherwise transfer this device. We ask that you charge the Fitbit during the day and wear the Fitbit anytime it is not charging. On a regular basis, data will be downloaded from your device over the web. This information will consist of behavioral measures such as steps walked, blood pressure, heartrate, blood oxygen level, and sleep. The data will be collected from FitBit's servers and accessed by the UTSA research team. After being received from FitBit, all fitness tracking data is automatically anonymized and stored on a secure server to prevent any unauthorized parties from gaining access to or using the data to identify you. If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted. A Fitbit tracker will be provided to be used over the course of the study, and if you agree to allow us long-term monitoring of your physical activity, you may keep it after the completion of the study.
1) Activity tracking
2) Blood sample: This study will generally involve one visit every 6 months in which 1-3 tubes of blood will be obtained for research purposes. Subjects included in an intervention will be required to give blood before, during, and after the intervention is complete. Blood sample for adults weighing 110lbs will not exceed 550mL in an 8 week period and blood draw will not occur more frequently than 2 times per week. For adult subjects less than 110lbs, the amount drawn will not exceed the lesser of 50mL or 3mL/kg in an 8 week period and blood draw will not occur more frequently than 2 times per week. Blood will be collected from a participating lab. Participants will be assigned a numbered identifier, and all blood samples will be marked with that number only. Blood samples will be stored at UTSA, or with a collaborator pending testing. All unused blood will be stored at UTSA indefinitely or disposed of. If a participant wishes to withdraw from the study, we may request to keep specimens collected up until the point participant withdrew. The participant may elect to allow us to keep the specimen and use it for research purposes, or they may ask for it to be disposed of.
2) Blood sample
3) Non-invasive imaging: This study will use fMRI, PET and OCT scans. This data is important to chart how the biology of the brain is changing over time. All scans will be done at collaborating research sites for research purposes only. Images and scans will be marked with the participant's numbered identifier only. Digital images will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep images collected up until the point participant withdrew. The participant may elect to allow us to keep the images and use it for research purposes, or they may ask for it to be disposed of.
3) Non-invasive imaging
4) Polysomnography(PSG): This study will use PSG (sleep study) to detect sleep stages and other characteristics of sleep. This data will be used to detect EEG and sleep architecture. PSG will be performed at collaborating research sites for research purposes only. Subjects who agree to wear a tracking device during a polysomnograph will release all sleep study data to the Quantu research team. PSG will be marked with the participants numbered identifier only. PSG data will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep PSG data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be disposed of.
4) Polysomnography(PSG)
5) Cognitive Testing: This study will use cognitive testing via website/app to establish baseline cognitive function and monitor changes in cognitive ability over the course of the study.
5) Cognitive Testing
6) One night PSG + Fitbit: Subjects who are already having a PSG procedure can opt to wear a Fitbit during the night of the procedure for comparison studies. The Fitbit will be returned to sleep lab personnel after the completion of the sleep study. Subjects are welcome to join the long term study if they choose. Subjects who agree to wear a tracking device during a polysomnograph will release all sleep study data to the Quantu research team. PSG will be marked with the participants numbered identifier only. PSG data will be stored at UTSA indefinitely. If a participant wishes to withdraw from the study, we may request to keep PSG data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be disposed of.
6) One night PSG + Fitbit
7) Cognitive Training Intervention: You will be asked to do a series of cognitive training exercises via app or remote learning for 6 weeks - 6 months. You will be asked to give blood prior to the start of the intervention, during the intervention, and after the intervention. After the intervention is completed, you will continue to be racked via Fitbit tracker and 6 month blood draws (from the data of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes. or they may ask for it to be deleted.
7) Cognitive Training Intervention
8) Exercise Intervention: You will be asked to increase your activity levels for 6 weeks - 6 months. You will either be provided with a goal (i.e. take 10,000 steps per day) that will increase your activity level by 5-30% or be required to take an online fitness class provided by the Quantu project. You will be asked to give blood prior to the start of the intervention and after the completion of the intervention. After the intervention is completed, you will continue to be tracked vid Fitbit tracker and 6 month blood draws (from the data of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted.
8) Exercise Intervention
9) UV Light Exposure Intervention: You will be given Luminette UV light therapy glasses which they will use in the morning for 30 minutes each day for 6 weeks - 6 months. You will give blood prior to the start of the intervention and after the completion of the intervention. After the intervention is completed, You will continue to be tracked via FitBit tracker and 6 month blood draws (from the date of post-intervention draw). If a participant wishes to withdraw from the study, we may request to keep data collected up until the point participant withdrew. The participant may elect to allow us to keep the data and use it for research purposes, or they may ask for it to be deleted.
9) UV Light Exposure Intervention
10) DNA Testing:
10) DNA Testing
You will be asked to perform several tests of olfaction (your capacity to distinguish odors). These noninvasive tests may be self-administered and involve distinguishing between different odors included in a disposable kit. You may be asked to self-score these tests and report your scores to the Quantu research team or you may be asked to submit your responses directly via an online form or application. All test scores are anonymized for reporting, and you may not receive your test scores.
Olfactory Testing
Due to the role viruses and bacteria may play in long-term neurovasculature, cardiac and cognitive health, you may be asked about the results of related tests (i.e. SARS-CoV-2 (COVID-19)). Additionally, you may opt to have a viral or antibody test performed by a clinical facility, in which case the results of this test may be reported to the Quantu research team. All test results are anonymized for reporting and are not used for clinical diagnosis or treatment.
Results of infectious disease testing
This will allow us to access activity data prior to you being enrolled in the study. (optional)
Prior activity tracker data
Parent or Guardian's Signature*
Electronic Signature Consent*
By checking here, you are consenting to the use of your electronic signature in lieu of an original signature on paper. You have the right to request that you sign a paper copy instead. By checking here, you are waiving that right. After consent, you may, upon written request to us, obtain a paper copy of an electronic record. No fee will be charged for such copy and no special hardware or software is required to view it. Your agreement to use an electronic signature with us for any documents will continue until such time as you notify us in writing that you no longer wish to use an electronic signature. There is no penalty for withdrawing your consent. You should always make sure that we have a current email address in order to contact you regarding any changes, if necessary.


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